| Blue Beetle (2023)As Victoria Kord | (Not seen) |
| Maybe I Do (2023)As Monica | (Not seen) |
| Jolt (2021)As Woman with No Name | (Not seen) |
| A Bad Moms Christmas (2017)As Isis Dunkler | (Not seen) |
| Zoolander 2 (2016) (AKA "2oolander")As Susan Sarandon (uncredited) | (Not seen) |
| Avril et le monde truqué (2015) (AKA "April and the Extraordinary World")As Chimène (English DUB) | (Not seen) |
| Tammy (2014)As Pearl | (Not seen) |
| The Calling (2014)As Hazel Micallef | (Not seen) |
| Snitch (2013)As Joanne Keeghan | (Not seen) |
| The Big Wedding (2013)As Bebe McBride | (Not seen) |
| Robot & Frank (2012)As Jennifer | (Not seen) |
| That's My Boy (2012)As Mary McGarricle | (Not seen) |
| The Company You Keep (2012)As Sharon Solarz | (Not seen) |
| The Perks of Being a Wallflower (2012) | (Not seen) |
| Arbitrage (2012)As Ellen Miller | (Not seen) |
| Cloud Atlas (2012)As Madame Horrox / Older Ursula / Yusouf Suleiman / Abbess | (Not seen) |
| Jeff, Who Lives at Home (2011)As Sharon | (Not seen) |
| Fight for Your Right Revisited (2011)As Mother | (Not seen) |
| You Don't Know Jack (2010)As Janet Good | (Not seen) |
| Wall Street: Money Never Sleeps (2010) (AKA "Wall Street")As Sylvia Moore | (Not seen) |
| Peacock (2010)As Fanny Crill | (Not seen) |
| The Greatest (2009)As Grace Brewer | (Not seen) |
| Solitary Man (2009)As Nancy | (Not seen) |
| Leaves of Grass (2009)As Daisy Kincaid | (Not seen) |
| The Lovely Bones (2009)As Grandma Lynn | (Not seen) |
| Speed Racer (2008) (AKA "Speed Racer: The IMAX Experience")As Mom Racer | (Not seen) |
| Saturday Night Live in the '90s: Pop Culture Nation (2007) | (Not seen) |
| In the Valley of Elah (2007)As Joan Deerfield | (Not seen) |
| Enchanted (2007)As Queen Narissa | (Not seen) |
| Mr. Woodcock (2007)As Beverly Farley | (Not seen) |
| Bernard and Doris (2006)As Doris Duke | (Not seen) |
| Elizabethtown (2005)As Hollie Baylor | (Not seen) |
| Shall We Dance (2004) (AKA "Shall We Dance?")As Beverly Clark | (Not seen) |
| Alfie (2004)As Liz | (Not seen) |
| The Banger Sisters (2002)As Lavinia | (Not seen) |
| Moonlight Mile (2002) (AKA "Baby's in Black")As Jojo Floss | (Not seen) |
| Igby Goes Down (2002)As Mimi Slocumb | (Not seen) |
| Cats & Dogs (2001)As Ivy (voice) | (Not seen) |
| Rugrats in Paris: The Movie (2000)As Coco LaBouche (voice) | (Not seen) |
| Anywhere But Here (1999)As Adele August | (Not seen) |
| Cradle Will Rock (1999)As Margherita Sarfatti | (Not seen) |
| Stepmom (1998) (AKA "Good Night Moon")As Jackie Harrison | (Not seen) |
| Twilight (1998) (AKA "The Magic Hour")As Catherine Ames | (Not seen) |
| James and the Giant Peach (1996)As Miss Spider (voice) | (Not seen) |
| The Celluloid Closet (1995)As Herself | (Not seen) |
| Dead Man Walking (1995)As Sister Helen Prejean | (Not seen) |
| Safe Passage (1994)As Margaret "Mag" Singer | (Not seen) |
| Little Women (1994)As Mrs. Abigail "Marmee" March | (Not seen) |
| The Client (1994)As Regina "Reggie" Love | (Not seen) |
| Bob Roberts (1992)As Tawna Titan | (Not seen) |
| Light Sleeper (1992)As Ann | (Not seen) |
| Lorenzo's Oil (1992)As Michaela Odone | (Not seen) |
| The Player (1992)As Susan Sarandon | (Not seen) |
| Thelma & Louise (1991)As Louise Elizabeth Sawyer | (Not seen) |
| A Dry White Season (1989)As Melanie Bruwer | (Not seen) |
| The January Man (1989)As Christine Starkey | (Not seen) |
| Bull Durham (1988)As Annie Savoy | (Not seen) |
| The Witches of Eastwick (1987)As Jane Spofford | (Not seen) |
| The Hunger (1983)As Dr. Sarah Roberts | (Not seen) |
| Atlantic City (1980) (AKA "Atlantic City, USA")As Sally | (Not seen) |
| Pretty Baby (1978)As Hattie | (Not seen) |
| The Last of the Cowboys (1977) (AKA "The Great Smokey Roadblock")As Ginny | (Not seen) |
| The Rocky Horror Picture Show (1975)As Janet Weiss | (Not seen) |
| The Front Page (1974)As Peggy Grant | (Not seen) |