| Monsters University (2013)As Mike Wazowski (voice) | (Not seen) |
| Parental Guidance (2012)As Artie Decker | (Not seen) |
| I'm Still Here (2010) (AKA "I'm Still Here: The Lost Years of Joaquin Phoenix")As Himself | (Not seen) |
| Tooth Fairy (2010)As Jerry (uncredited) | (Not seen) |
| Sicko (2007)As Himself | (Not seen) |
| Cars (2006) (AKA "Route 66")As Mike Car (voice) | (Not seen) |
| Saturday Night Live in the '80s: Lost & Found (2005) (AKA "Saturday Night Live in the '80s: Lost and Found") | (Not seen) |
| Howl's Moving Castle (2004)As Calcifer (English version) (voice) | (Not seen) |
| Mike's New Car (2002)As Mike (voice) | (Not seen) |
| Analyze That (2002) (AKA "Analyze You")As Dr. Ben Sobel | (Not seen) |
| As You Wish: The Story of 'The Princess Bride' (2001)As Self | (Not seen) |
| America's Sweethearts (2001)As Lee Phillips | (Not seen) |
| Monsters, Inc. (2001)As Mike Wazowski (voice) | (Not seen) |
| The Adventures of Rocky & Bullwinkle (2000)As Mattress Salesman | (Not seen) |
| Analyze This (1999) (AKA "Analyze Me")As Dr. Ben Sobel | (Not seen) |
| Deconstructing Harry (1997) (AKA "The Meanest Man in the World")As Larry/The Devil | (Not seen) |
| Fathers' Day (1997)As Jack Lawrence | (Not seen) |
| Hamlet (1996) (AKA "William Shakespeare's Hamlet")As First Gravedigger | (Not seen) |
| City Slickers II: The Legend of Curly's Gold (1994) (AKA "City Slickers II")As Mitch Robbins | (Not seen) |
| City Slickers (1991)As Mitch Robbins | (Not seen) |
| When Harry Met Sally... (1989) (AKA "Harry, This Is Sally")As Harry Burns | (Not seen) |
| Throw Momma from the Train (1987)As Larry Donner | (Not seen) |
| The Princess Bride (1987) (AKA "The Bridges' Bride")As Miracle Max | (Not seen) |
| Running Scared (1986)As Danny Costanzo | (Not seen) |
| This Is Spinal Tap (1984) (AKA " This is Spinal Tap®: A Rockumentary by Martin Di Bergi")As Morty the Mime | (Not seen) |