| The Odyssey (2026) As Odysseus | (Not seen) |
| The Instigators (2024) As Rory | (Not seen) |
| IF (2024) As Flower (voice) | (Not seen) |
| Drive-Away Dolls (2024) As Senator Gary Channel | (Not seen) |
| Air (2023) (AKA "Air: Courting a Legend") As Sonny Vaccaro | (Not seen) |
| Oppenheimer (2023) As Leslie Groves | (Not seen) |
| Thor: Love and Thunder (2022) As Actor Loki | (Not seen) |
| The Last Duel (2021) As Jean de Carrouges | (Not seen) |
| Stillwater (2021) As Bill Baker | (Not seen) |
| Jay and Silent Bob Reboot (2019) As Loki | (Not seen) |
| Ford v Ferrari (2019) As Carroll Shelby | (Not seen) |
| Unsane (2018) As Detective Ferguson | (Not seen) |
| Deadpool 2 (2018) As Redneck #2 | (Not seen) |
| Downsizing (2017) As Paul Safranek | (Not seen) |
| Suburbicon (2017) As Gardner Lodge | (Not seen) |
| Thor: Ragnarok (2017) As Actor Loki (uncredited) | (Not seen) |
| The Great Wall (2016) As William Garin | (Not seen) |
| Jason Bourne (2016) As Jason Bourne | (Not seen) |
| The Martian (2015) (AKA "The Martian 3D") As Mark Watney | (Not seen) |
| Interstellar (2014) As Dr. Mann | (Not seen) |
| The Monuments Men (2014) As Lt. James Granger | (Not seen) |
| Behind the Candelabra (2013) As Scott Thorson | (Not seen) |
| The Zero Theorem (2013) As Management | (Not seen) |
| Elysium (2013) As Max | (Not seen) |
| Promised Land (2012) As Steve Butler | (Not seen) |
| Happy Feet Two (2011) As Bill (voice) | (Not seen) |
| We Bought a Zoo (2011) As Benjamin Mee | (Not seen) |
| Contagion (2011) (AKA "Contagion: The IMAX Experience") As Mitch Emhoff | (Not seen) |
| The Adjustment Bureau (2011) (AKA "Adjustment") As David Norris | (Not seen) |
| Inside Job (2010) As Narrator | (Not seen) |
| Hereafter (2010) As George Lonegan | (Not seen) |
| True Grit (2010) As LaBoeuf | (Not seen) |
| Green Zone (2010) As Roy Miller | (Not seen) |
| The People Speak (2009) As Himself | (Not seen) |
| The Informant! (2009) As Mark Whitacre | (Not seen) |
| Invictus (2009) (AKA "The Human Factor") As Francois Pienaar | (Not seen) |
| Che: Part Two (2008) (AKA "Guerrilla") As Fr. Schwartz | (Not seen) |
| Ponyo (2008) | (Not seen) |
| Youth Without Youth (2007) As Life Magazine Reporter | (Not seen) |
| The Bourne Ultimatum (2007) As Jason Bourne | (Not seen) |
| Ocean's Thirteen (2007) (AKA "13") As Linus Caldwell | (Not seen) |
| The Good Shepherd (2006) As Edward Bell Wilson | (Not seen) |
| The Departed (2006) (AKA "Infernal Affairs") As Staff Sgt. Colin Sullivan | (Not seen) |
| Syriana (2005) (AKA "See No Evil") As Bryan Woodman | (Not seen) |
| The Brothers Grimm (2005) As Wilhelm Grimm | (Not seen) |
| Jersey Girl (2004) (AKA "Fatherhood Project") As PR Exec #2 | (Not seen) |
| Ocean's Twelve (2004) (AKA "Ocean's 12") As Linus Caldwell | (Not seen) |
| The Bourne Supremacy (2004) As Jason Bourne | (Not seen) |
| EuroTrip (2004) (AKA "Fistful of Euros") As Donny | (Not seen) |
| Stuck on You (2003) As Bob | (Not seen) |
| Confessions of a Dangerous Mind (2002) (AKA "Confession") As Bachelor Matt | (Not seen) |
| Gerry (2002) As Gerry | (Not seen) |
| The Bourne Identity (2002) As Jason Bourne | (Not seen) |
| The Majestic (2001) (AKA "The Bijou") As Luke Trimble (voice) | (Not seen) |
| Jay and Silent Bob Strike Back (2001) As Matt Damon / Will Hunting (uncredited) | (Not seen) |
| Ocean's Eleven (2001) (AKA "11") As Linus Caldwell | (Not seen) |
| All the Pretty Horses (2000) As John Grady Cole | (Not seen) |
| Titan A.E. (2000) (AKA "Planet Ice") As Cale Tucker (voice) | (Not seen) |
| Finding Forrester (2000) As Steven Sanderson | (Not seen) |
| The Legend of Bagger Vance (2000) As Rannulph Junuh | (Not seen) |
| The Talented Mr. Ripley (1999) As Tom Ripley | (Not seen) |
| Dogma (1999) (AKA "Bearclaw") As Loki | (Not seen) |
| Rounders (1998) As Mike McDermott | (Not seen) |
| Saving Private Ryan (1998) As Private James Francis Ryan | (Not seen) |
| The Rainmaker (1997) (AKA "John Grisham's The Rainmaker") As Rudy Baylor | (Not seen) |
| Chasing Amy (1997) As Shawn Oran | (Not seen) |
| Good Will Hunting (1997) As Will Hunting | (Not seen) |
| Courage Under Fire (1996) As Ilario | (Not seen) |
| School Ties (1992) As Charlie Dillon | (Not seen) |
| Field of Dreams (1989) As Baseball Fan at Fenway Park (uncredited) | (Not seen) |
| Mystic Pizza (1988) As Steamer | (Not seen) |