| Spider-Man: Across the Spider-Verse (2023)As Doc Ock (voice) | (Not seen) |
| Glass Onion: A Knives Out Mystery (2022)As Claire Debella | (Not seen) |
| Private Life (2018)As Rachel Biegler | (Not seen) |
| Spider-Man: Into the Spider-Verse (2018)As Olivia 'Liv' Octavius / Doc Ock (voice) | (Not seen) |
| Hotel Transylvania 3: Summer Vacation (2018)As Ericka Van Helsing (voice) | (Not seen) |
| A Bad Moms Christmas (2017)As Carla Dunkler | (Not seen) |
| The Do-Over (2016)As Becca | (Not seen) |
| Captain Fantastic (2016)As Harper | (Not seen) |
| The Visit (2015)As Mother | (Not seen) |
| The D Train (2015)As Stacey Landsman | (Not seen) |
| Tomorrowland (2015)As Ursula | (Not seen) |
| She's Funny That Way (2014) (AKA "My Funny Lady")As Delta Simmons | (Not seen) |
| This Is Where I Leave You (2014)As Annie Altman | (Not seen) |
| Bad Words (2013)As Jenny Widgeon | (Not seen) |
| The Secret Life of Walter Mitty (2013)As Odessa Mitty | (Not seen) |
| We're the Millers (2013)As Edie Fitzgerald | (Not seen) |
| Wanderlust (2012)As Karen | (Not seen) |
| The Dictator (2012)As Pregnant Woman | (Not seen) |
| Our Idiot Brother (2011) (AKA "My Idiot Brother")As Janet Ziebell | (Not seen) |
| How Do You Know (2010)As Annie | (Not seen) |
| The Goods: Live Hard, Sell Hard (2009)As Babs Merrick | (Not seen) |
| Revolutionary Road (2008)As Milly Campbell | (Not seen) |
| Step Brothers (2008)As Alice | (Not seen) |
| The Last Mimzy (2007)As Naomi Schwartz | (Not seen) |
| The Holiday (2006)As Bristol | (Not seen) |
| A Lot Like Love (2005)As Michelle | (Not seen) |
| Wake Up, Ron Burgundy: The Lost Movie (2004) (AKA "Anchorman: Wake-Up Ron Burgundy")As Helen | (Not seen) |
| Win a Date with Tad Hamilton! (2004)As Angelica | (Not seen) |
| Anchorman: The Legend of Ron Burgundy (2004) (AKA "Action News")As Helen | (Not seen) |
| How to Lose a Guy in 10 Days (2003) (AKA "How to Lose a Guy")As Michelle Rubin | (Not seen) |