| Faye (2024) | (Not seen) |
| Mother Couch (2023) (AKA "Mother, Couch!")As Mother | (Not seen) |
| The Exorcist: Believer (2023)As Chris MacNeil | (Not seen) |
| Queen Bees (2021)As Helen Wilson | (Not seen) |
| Pieces of a Woman (2020)As Elizabeth Weiss | (Not seen) |
| The Age of Adaline (2015)As Flemming | (Not seen) |
| When Marnie Was There (2014) (AKA "Omoide no Mani") | (Not seen) |
| The Calling (2014)As Emily Micallef | (Not seen) |
| Interstellar (2014)As Old Murph Cooper | (Not seen) |
| Draft Day (2014)As Barb Weaver | (Not seen) |
| W. (2008) (AKA "Bush")As Barbara Bush | (Not seen) |
| The Stone Angel (2007)As Hagar | (Not seen) |
| The Wicker Man (2006) (AKA "Wicker Man - Ritual des Bosen")As Sister Summersisle | (Not seen) |
| The Fountain (2006) (AKA "The Last Man")As Dr. Lillian Guzetti | (Not seen) |
| Easy Riders, Raging Bulls: How the Sex, Drugs and Rock 'N' Roll Generation Saved Hollywood (2003)As Herself | (Not seen) |
| Red Dragon (2002) (AKA "Roter Drache")As Grandma Dolarhyde (voice) (uncredited) | (Not seen) |
| Requiem for a Dream (2000)As Sara Goldfarb | (Not seen) |
| The Yards (2000)As Val Handler | (Not seen) |
| Walking Across Egypt (1999) (AKA "Leading with Her Heart")As Mattie Rigsbee | (Not seen) |
| The Hurricane (1999) (AKA "Lazarus and the Hurricane") | (Not seen) |
| Playing by Heart (1998) (AKA "Dancing About Architecture")As Mildred | (Not seen) |
| How to Make an American Quilt (1995)As Hy Dodd | (Not seen) |
| When a Man Loves a Woman (1994)As Emily | (Not seen) |
| Dying Young (1991) (AKA "The Choice of Love")As Mrs. O'Neil | (Not seen) |
| Hanna's War (1988)As Katalin | (Not seen) |
| Act of Vengeance (1986)As Margaret Yablonski | (Not seen) |
| A Dream of Passion (1978) (AKA "Kravgi gynaikon")As Brenda Collins | (Not seen) |
| Same Time, Next Year (1978)As Doris | (Not seen) |
| Harry and Tonto (1974)As Shirley Mallard | (Not seen) |
| Alice Doesn't Live Here Anymore (1974)As Alice Hyatt | (Not seen) |
| The Exorcist (1973)As Chris MacNeil | (Not seen) |
| The Last Picture Show (1971)As Lois Farrow | (Not seen) |
| Alex in Wonderland (1970)As Beth Morrison | (Not seen) |