| Joker: Folie à Deux (2024) | (Not seen) |
| The Adam Project (2022)As Maya Sorian | (Not seen) |
| The Croods: A New Age (2020)As Ugga Crood (voice) | (Not seen) |
| Sicario: Day of the Soldado (2018)As Cynthia Foards | (Not seen) |
| Incredibles 2 (2018)As Evelyn Deavor (voice) | (Not seen) |
| Get Out (2017)As Missy Armitage | (Not seen) |
| Enough Said (2013)As Marianne | (Not seen) |
| Begin Again (2013) (AKA "Can a Song Save Your Life?")As Miriam Hart | (Not seen) |
| Captain Phillips (2013)As Andrea Phillips | (Not seen) |
| The Croods (2013)As Ugga Crood (voice) | (Not seen) |
| Trust (2010)As Lynn Cameron | (Not seen) |
| Percy Jackson & the Olympians: The Lightning Thief (2010) (AKA "Percy Jackson and the Lightning Thief")As Sally Jackson | (Not seen) |
| The Soloist (2009)As Mary Weston | (Not seen) |
| Where the Wild Things Are (2009)As Connie | (Not seen) |
| Synecdoche, New York (2008)As Adele Lack | (Not seen) |
| What Just Happened (2008)As Lou Tarnow | (Not seen) |
| An American Crime (2007)As Gertrude Baniszewski | (Not seen) |
| Into the Wild (2007)As Jan Burres | (Not seen) |
| Friends with Money (2006)As Christine | (Not seen) |
| The Ballad of Jack and Rose (2005) (AKA "Rose and the Snake")As Kathleen | (Not seen) |
| The 40 Year Old Virgin (2005) (AKA "The 40 Year-Old Virgin")As Trish Piedmont | (Not seen) |
| Capote (2005)As Harper Lee | (Not seen) |
| The Interpreter (2005)As Dot Woods | (Not seen) |
| S1m0ne (2002) (AKA "Simone")As Elaine Christian | (Not seen) |
| Full Frontal (2002) (AKA "How to Survive a Hotel Room Fire")As Lee | (Not seen) |
| Adaptation. (2002) (AKA "The Orchid Thief")As Herself (uncredited) | (Not seen) |
| Death to Smoochy (2002)As Nora Wells | (Not seen) |
| Being John Malkovich (1999)As Maxine Lund | (Not seen) |
| 8MM (1999) (AKA "8 Millimeter")As Amy Welles | (Not seen) |
| Your Friends & Neighbors (1998) (AKA "Friends and Neighbors")As Terri | (Not seen) |
| Out of Sight (1998)As Adele | (Not seen) |
| The Real Blonde (1997)As Mary | (Not seen) |
| Living in Oblivion (1995)As Nicole Springer | (Not seen) |
| Switch (1991) (AKA "Blake Edwards' Switch")As Steve's Secretary | (Not seen) |