| Despicable Me 4 (2024) As Gru (voice) | (Not seen) |
| IF (2024) As Blue (voice) | (Not seen) |
| Asteroid City (2023) As Motel Manager | (Not seen) |
| Minions: The Rise of Gru (2022) As Gru (voice) | (Not seen) |
| Irresistible (2020) As Gary Zimmer | (Not seen) |
| Vice (2018) As Donald Rumsfeld | (Not seen) |
| Despicable Me 3 (2017) As Gru / Dru (voice) | (Not seen) |
| Cafe Society (2016) (AKA "Café Society") As Phil Stern | (Not seen) |
| The Big Short (2015) As Mark Baum | (Not seen) |
| Minions (2015) As Gru (voice) | (Not seen) |
| Alexander and the Terrible, Horrible, No Good, Very Bad Day (2014) As Ben Cooper | (Not seen) |
| Foxcatcher (2014) (AKA "Mark v. Du Pont: The True Story of a Shocking Murder") As John du Pont | (Not seen) |
| Anchorman 2: The Legend Continues (2013) (AKA "Anchorman 2") As Brick Tamland | (Not seen) |
| The Way Way Back (2013) (AKA "The Way, Way Back") As Trent Ramsey | (Not seen) |
| Despicable Me 2 (2013) As Gru (voice) | (Not seen) |
| The Incredible Burt Wonderstone (2013) As Burt Wonderstone | (Not seen) |
| Seeking a Friend for the End of the World (2012) As Dodge Petersen | (Not seen) |
| Crazy, Stupid, Love. (2011) (AKA "Love Again") As Cal Weaver | (Not seen) |
| Dinner for Schmucks (2010) (AKA "The Dinner") As Barry | (Not seen) |
| Despicable Me (2010) As Gru (voice) | (Not seen) |
| Date Night (2010) As Phil Foster | (Not seen) |
| Horton Hears a Who! (2008) (AKA "Dr. Seuss' Horton Hears a Who") As The Mayor of Whoville (voice) | (Not seen) |
| Get Smart (2008) As Maxwell Smart | (Not seen) |
| Dan in Real Life (2007) As Dan Burns | (Not seen) |
| Knocked Up (2007) As Himself (uncredited) | (Not seen) |
| Evan Almighty (2007) (AKA "Bruce Almighty 2") As Evan Baxter | (Not seen) |
| Over the Hedge (2006) As Hammy (voice) | (Not seen) |
| Little Miss Sunshine (2006) As Frank Ginsberg | (Not seen) |
| Bewitched (2005) As Uncle Arthur | (Not seen) |
| The 40 Year Old Virgin (2005) (AKA "The 40 Year-Old Virgin") As Andy Stitzer | (Not seen) |
| Wake Up, Ron Burgundy: The Lost Movie (2004) (AKA "Anchorman: Wake-Up Ron Burgundy") As Brick Tamland | (Not seen) |
| Melinda and Melinda (2004) (AKA "Melinda & Melinda") As Walt | (Not seen) |
| Anchorman: The Legend of Ron Burgundy (2004) (AKA "Action News") As Brick Tamland | (Not seen) |
| Bruce Almighty (2003) As Evan Baxter | (Not seen) |
| Homegrown (1998) (AKA "Wild Smokers") As Party Extra with Funny Pants (uncredited) | (Not seen) |
| Curly Sue (1991) As Tesio | (Not seen) |