| SNL50: The Homecoming Concert (2025) | (Not seen) |
| Ezra (2023) As Jayne | (Not seen) |
| Luck (2022) As Captain (voice) | (Not seen) |
| Till (2022) As Alma | (Not seen) |
| JFK Revisited: Through the Looking Glass (2021) As Narrator (voice) | (Not seen) |
| I Am Mother (2019) As Self (archive footage) (uncredited) | (Not seen) |
| Vice (2018) As Self (archive footage) | (Not seen) |
| Top Five (2014) As Herself | (Not seen) |
| Teenage Mutant Ninja Turtles (2014) As Bernadette Thompson | (Not seen) |
| Blackfish (2013) As Self | (Not seen) |
| A Little Bit of Heaven (2011) As God | (Not seen) |
| The Muppets (2011) As Self | (Not seen) |
| Toy Story 3 (2010) (AKA "3") As Stretch (voice) | (Not seen) |
| Madea Goes to Jail (2009) (AKA "Tyler Perry's Madea Goes to Jail") As Whoopi | (Not seen) |
| Everyone's Hero (2006) As Darlin' (voice) | (Not seen) |
| Doogal (2006) As Ermintrude (voice) | (Not seen) |
| The Pacifier (2005) (AKA "Gnome") | (Not seen) |
| The Lion King 1½ (2004) As Shenzi (voice) | (Not seen) |
| Superbabies: Baby Geniuses 2 (2004) As Whoopi Goldberg | (Not seen) |
| Pauly Shore Is Dead (2003) As Whoopi Goldberg | (Not seen) |
| It's a Very Merry Muppet Christmas Movie (2002) As Daniel's 'Boss' | (Not seen) |
| Star Trek: Nemesis (2002) As Guinan | (Not seen) |
| Monkeybone (2001) As Death | (Not seen) |
| Rat Race (2001) As Vera Baker | (Not seen) |
| The Adventures of Rocky & Bullwinkle (2000) As Judge Cameo | (Not seen) |
| Alice in Wonderland (1999) As Cheshire Cat | (Not seen) |
| The Deep End of the Ocean (1999) As Candy Bliss | (Not seen) |
| Girl, Interrupted (1999) As Valerie Owens | (Not seen) |
| "The Wonderful World of Disney" A Knight in Camelot (1998) As Dr. Vivien Morgan | (Not seen) |
| The Rugrats Movie (1998) As Ranger Margaret (voice) | (Not seen) |
| In & Out (1997) As Whoopi Goldberg (uncredited) | (Not seen) |
| Bogus (1996) As Harriet Franklin | (Not seen) |
| Ghosts of Mississippi (1996) (AKA "Ghosts from the Past") As Myrlie Evers | (Not seen) |
| Bordello of Blood (1996) (AKA "Dead Easy") As Hospital Patient (uncredited) | (Not seen) |
| Eddie (1996) As Eddie Franklin | (Not seen) |
| The Celluloid Closet (1995) As Herself | (Not seen) |
| Theodore Rex (1995) As Katie Coltrane | (Not seen) |
| Boys on the Side (1995) As Jane Deluca | (Not seen) |
| Corrina, Corrina (1994) As Corrina Washington | (Not seen) |
| The Pagemaster (1994) As Fantasy (voice) | (Not seen) |
| The Little Rascals (1994) As Buckwheat's Mom | (Not seen) |
| The Lion King (1994) (AKA "The Lion King 3D") As Shenzi the Hyena (voice) | (Not seen) |
| Star Trek: Generations (1994) (AKA "Star Trek 7") As Guinan | (Not seen) |
| Made in America (1993) As Sarah Mathews | (Not seen) |
| Sister Act 2: Back in the Habit (1993) As Deloris Van Cartier | (Not seen) |
| Loaded Weapon 1 (1993) (AKA "National Lampoon's Loaded Weapon 1") As Billy York | (Not seen) |
| Sarafina! (1992) As Mary Masembuko | (Not seen) |
| The Player (1992) As Susan Avery | (Not seen) |
| Sister Act (1992) As Deloris Van Cartier/Sister Mary Clarence | (Not seen) |
| Soapdish (1991) As Rose Schwartz | (Not seen) |
| House Party 2 (1991) As Professor | (Not seen) |
| Ghost (1990) As Oda Mae Brown | (Not seen) |
| Homer and Eddie (1989) As Eddie Cervi | (Not seen) |
| Fatal Beauty (1987) As Rita Rizzoli | (Not seen) |
| Jumpin' Jack Flash (1986) (AKA "Knock, Knock") As Terry Dolittle | (Not seen) |
| The Color Purple (1985) As Celie Harris Johnson | (Not seen) |