| SNL50: The Homecoming Concert (2025) | (Not seen) |
| Ezra (2023)As Jayne | (Not seen) |
| Luck (2022)As Captain (voice) | (Not seen) |
| Till (2022)As Alma | (Not seen) |
| JFK Revisited: Through the Looking Glass (2021)As Narrator (voice) | (Not seen) |
| I Am Mother (2019)As Self (archive footage) (uncredited) | (Not seen) |
| Vice (2018)As Self (archive footage) | (Not seen) |
| Top Five (2014)As Herself | (Not seen) |
| Teenage Mutant Ninja Turtles (2014)As Bernadette Thompson | (Not seen) |
| Blackfish (2013)As Self | (Not seen) |
| A Little Bit of Heaven (2011)As God | (Not seen) |
| The Muppets (2011)As Self | (Not seen) |
| Toy Story 3 (2010) (AKA "3")As Stretch (voice) | (Not seen) |
| Madea Goes to Jail (2009) (AKA "Tyler Perry's Madea Goes to Jail")As Whoopi | (Not seen) |
| Everyone's Hero (2006)As Darlin' (voice) | (Not seen) |
| Doogal (2006)As Ermintrude (voice) | (Not seen) |
| The Pacifier (2005) (AKA "Gnome") | (Not seen) |
| The Lion King 1½ (2004)As Shenzi (voice) | (Not seen) |
| Superbabies: Baby Geniuses 2 (2004)As Whoopi Goldberg | (Not seen) |
| Pauly Shore Is Dead (2003)As Whoopi Goldberg | (Not seen) |
| It's a Very Merry Muppet Christmas Movie (2002)As Daniel's 'Boss' | (Not seen) |
| Star Trek: Nemesis (2002)As Guinan | (Not seen) |
| Monkeybone (2001)As Death | (Not seen) |
| Rat Race (2001)As Vera Baker | (Not seen) |
| The Adventures of Rocky & Bullwinkle (2000)As Judge Cameo | (Not seen) |
| Alice in Wonderland (1999)As Cheshire Cat | (Not seen) |
| The Deep End of the Ocean (1999)As Candy Bliss | (Not seen) |
| Girl, Interrupted (1999)As Valerie Owens | (Not seen) |
| "The Wonderful World of Disney" A Knight in Camelot (1998)As Dr. Vivien Morgan | (Not seen) |
| The Rugrats Movie (1998)As Ranger Margaret (voice) | (Not seen) |
| In & Out (1997)As Whoopi Goldberg (uncredited) | (Not seen) |
| Bogus (1996)As Harriet Franklin | (Not seen) |
| Ghosts of Mississippi (1996) (AKA "Ghosts from the Past")As Myrlie Evers | (Not seen) |
| Bordello of Blood (1996) (AKA "Dead Easy")As Hospital Patient (uncredited) | (Not seen) |
| Eddie (1996)As Eddie Franklin | (Not seen) |
| The Celluloid Closet (1995)As Herself | (Not seen) |
| Theodore Rex (1995)As Katie Coltrane | (Not seen) |
| Boys on the Side (1995)As Jane Deluca | (Not seen) |
| Corrina, Corrina (1994)As Corrina Washington | (Not seen) |
| The Pagemaster (1994)As Fantasy (voice) | (Not seen) |
| The Little Rascals (1994)As Buckwheat's Mom | (Not seen) |
| The Lion King (1994) (AKA "The Lion King 3D")As Shenzi the Hyena (voice) | (Not seen) |
| Star Trek: Generations (1994) (AKA "Star Trek 7")As Guinan | (Not seen) |
| Made in America (1993)As Sarah Mathews | (Not seen) |
| Sister Act 2: Back in the Habit (1993)As Deloris Van Cartier | (Not seen) |
| Loaded Weapon 1 (1993) (AKA "National Lampoon's Loaded Weapon 1")As Billy York | (Not seen) |
| Sarafina! (1992)As Mary Masembuko | (Not seen) |
| The Player (1992)As Susan Avery | (Not seen) |
| Sister Act (1992)As Deloris Van Cartier/Sister Mary Clarence | (Not seen) |
| Soapdish (1991)As Rose Schwartz | (Not seen) |
| House Party 2 (1991)As Professor | (Not seen) |
| Ghost (1990)As Oda Mae Brown | (Not seen) |
| Homer and Eddie (1989)As Eddie Cervi | (Not seen) |
| Fatal Beauty (1987)As Rita Rizzoli | (Not seen) |
| Jumpin' Jack Flash (1986) (AKA "Knock, Knock")As Terry Dolittle | (Not seen) |
| The Color Purple (1985)As Celie Harris Johnson | (Not seen) |