| The Room Next Door (2024)As Ingrid | (Not seen) |
| May December (2023)As Gracie | (Not seen) |
| Sharper (2023)As Madeline Phillips | (Not seen) |
| When You Finish Saving the World (2022) (AKA "When You Finish Saving the World")As Evelyn | (Not seen) |
| The Woman in the Window (2021)As Katie | (Not seen) |
| The Glorias (2020)As Gloria Steinem | (Not seen) |
| Suburbicon (2017)As Margaret Lodge / Rose | (Not seen) |
| Kingsman: The Golden Circle (2017)As Poppy | (Not seen) |
| The Hunger Games: Mockingjay - Part 2 (2015)As President Alma Coin | (Not seen) |
| Seventh Son (2014)As Mother Malkin | (Not seen) |
| Still Alice (2014)As Dr. Alice Howland | (Not seen) |
| Maps to the Stars (2014)As Havana Segrand | (Not seen) |
| The Hunger Games: Mockingjay - Part 1 (2014)As President Alma Coin | (Not seen) |
| Non-Stop (2014)As Jen Summers | (Not seen) |
| Carrie (2013)As Margaret White | (Not seen) |
| Don Jon (2013) (AKA "Don Jon's Addiction")As Esther | (Not seen) |
| What Maisie Knew (2012)As Susanna | (Not seen) |
| Crazy, Stupid, Love. (2011) (AKA "Love Again")As Emily Weaver | (Not seen) |
| Elektra Luxx (2010)As Virgin Mary | (Not seen) |
| The Kids Are All Right (2010)As Jules | (Not seen) |
| 6 Souls (2010) (AKA "Shelter")As Cara Harding | (Not seen) |
| Chloe (2009)As Catherine Stewart | (Not seen) |
| A Single Man (2009) (AKA "Single Man")As Charley | (Not seen) |
| The Private Lives of Pippa Lee (2009)As Kat | (Not seen) |
| Blindness (2008)As Doctor's Wife | (Not seen) |
| Eagle Eye (2008) (AKA "Eagle Eye - Ausser Kontrolle")As ARIIA (voice) | (Not seen) |
| Saturday Night Live in the '90s: Pop Culture Nation (2007) | (Not seen) |
| Savage Grace (2007)As Barbara Baekeland | (Not seen) |
| I'm Not There. (2007) (AKA "I'm Not There")As Alice | (Not seen) |
| Next (2007)As Callie Ferris | (Not seen) |
| Freedomland (2006)As Brenda Martin | (Not seen) |
| Children of Men (2006)As Julian Taylor | (Not seen) |
| The Forgotten (2004) (AKA "Stranger")As Telly Paretta | (Not seen) |
| Far from Heaven (2002) (AKA "Loin du paradis")As Cathleen "Cathy" Whitaker | (Not seen) |
| The Hours (2002)As Laura Brown | (Not seen) |
| The Shipping News (2001)As Wavey Prowse | (Not seen) |
| Hannibal (2001) (AKA "The Silence of the Lambs 2")As Clarice M. Starling | (Not seen) |
| Evolution (2001)As Dr. Allison Reed, CDC | (Not seen) |
| That Moment: Magnolia Diary (2000) (AKA "That Moment: Magnolia Diary October 1998 - March 2000")As Herself | (Not seen) |
| The Ladies Man (2000) (AKA "The Ladies' Man")As Audrey | (Not seen) |
| Cookie's Fortune (1999)As Cora Duvall | (Not seen) |
| The End of the Affair (1999)As Sarah Miles | (Not seen) |
| An Ideal Husband (1999)As Mrs. Laura Cheveley | (Not seen) |
| Magnolia (1999) (AKA "mag-no'li-a")As Linda Partridge | (Not seen) |
| Psycho (1998)As Lila Crane | (Not seen) |
| The Big Lebowski (1998)As Maude Lebowski | (Not seen) |
| The Lost World: Jurassic Park (1997) (AKA "Jurassic Park 2")As Sarah Harding | (Not seen) |
| Boogie Nights (1997) (AKA "Pushing Thirteen")As Maggie alias Amber Waves | (Not seen) |
| Safe (1995) (AKA "Chemical Syndrome")As Carol White | (Not seen) |
| Nine Months (1995)As Rebecca Taylor | (Not seen) |
| Assassins (1995)As Electra | (Not seen) |
| Vanya on 42nd Street (1994)As Yelena | (Not seen) |
| Short Cuts (1993)As Marian Wyman | (Not seen) |
| Benny & Joon (1993)As Ruthie | (Not seen) |
| The Fugitive (1993)As Dr. Anne Eastman | (Not seen) |
| Body of Evidence (1992)As Sharon Dulaney | (Not seen) |
| The Hand That Rocks the Cradle (1992)As Marlene Craven | (Not seen) |
| Tales from the Darkside: The Movie (1990) (AKA "Creepshow 3")As Susan (segment "Lot 249") | (Not seen) |