A rookie FBI agent, Jo Dee Foster (Billy Zane), has been assigned to work on the case of the Psycho Killer, a killer who has killed over 120 people. But to find out more about the Psycho Killer, Jo is forced to meet Dr. Animal Cannibal Pizza (Dom DeLuise), a famous doctor turned cannibal who ate pizzas with human body parts. Meanwhile, Jo's girlfriend, Jane Wine (Charlene Tilton), has just stolen $400,000 in cash from her money-hungry boss, Mr. Laurel (Rip Taylor), so she and Jo can be happy, but gets lost in a really horrible storm, caused mostly by a special effects crew behind her car, and stops at the Cemetery Motel, where the owner, Antonio Motel (Ezio Greggio), is dominated by his insane mother ('Shelly Winters').