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On a routine red eye flight from Los Angeles to Paris, a renegade group of scientists has smuggled aboard a container holding a fellow scientist infected with a deadly genetically engineered virus which reanimates the dead. While the 747 crosses through violent thunderstorm, and no place to land, the flesh-eating zombies quickly spread the virus, infecting passengers and crew, the few survivors must fight for their lives stranded in the air with no way out.